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 Much progress has been made in the identification of key signaling pathways regulating blood vessel development. There is also evidence that various stromal cell types participate in normal and pathological angiogenesis in a tissue- or context-specific fashion. However, many important molecular and biological questions regarding these processes remain unanswered. In addition, several angiogenesis inhibitors have been approved by the FDA as therapy for cancer or intraocular neovascular disorders. Perhaps some of the most successful applications of anti-angiogenic therapy are in age-related macular degeneration and other intraocular neovascular diseases, although such findings have been rarely presented outside specialized meetings. The Keystone Symposia meeting on Angiogenesis: Advances in Basic Science and Therapeutic Applications will critically examine the latest basic science on the regulation of angiogenesis in health and disease, discuss the lessons from clinical trials in cancer and intraocular neovascular disorders and identify novel therapeutic targets. Additional discussion will focus on a renewed interest in therapeutic angiogenesis by tissue engineering or stem cell-based approaches.

在确定关键的信号通路调节血管的发展，已经取得了很大进展。还有证据表明，各种基质细胞在正常和病理的血管生成在一个组织或上下文特定的方式参与。然而，关于这些进程的许多重要的分子生物学和生物问题仍然没有答案。此外，一些血管生成抑制剂已被FDA批准作为治疗癌症或眼内新生血管性疾病。也许一些最成功的应用抗血管生成治疗的年龄相关性黄斑变性和其他眼内新生血管性疾病，虽然这样的结果已经很少以外的专门会议提出的。对血管生成的梯形专题讨论会会议：在基础科学和治疗应用的进展将仔细研究在健康和疾病的血管生成的调控上最新的基本的科学，讨论在肿瘤和眼内新生血管性疾病的临床试验的经验教训，确定新的治疗靶点。其他的讨论将集中于在治疗性血管生成的新的组织工程干细胞为基础的方法的兴趣。

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