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 Sirtuins comprise a unique class of NAD+-dependent enzymes that modify multiple protein substrates to execute diverse biological functions. Sirtuins are key regulators of clinically important cellular and organismal processes including metabolism, cell division and aging. The desire to understand the important determinants of human health and lifespan has resulted in a firestorm of work on the seven mammalian sirtuins in the past decade. The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has catapulted them to a prominent status as potential targets for nutritional and therapeutic development. The Keystone Symposia meeting on Sirtuins in Metabolism, Aging and Disease will address fundamental questions on the regulation, biochemical, molecular and cellular mechanisms and pathways of sirtuins. The significance of sirtuin-dependent regulation of homeostasis with respect to diverse biological organisms will be discussed. We envision that this meeting will evaluate the relevance of sirtuin biology in various human conditions, and provide a unique environment for discussing specific therapeutic strategies.
 
去乙酰化酶组成独特的一类NAD +人修改多个蛋白质基质酶执行多样的生物功能。去乙酰化酶是临床上常见的关键调节细胞和器官流程,包括代谢、细胞分裂和老化。希望了解人类的健康很重要的决定因素和寿命已经导致了一个风暴的工作去乙酰化酶七哺乳动物在过去的十年中。一词的含义在医疗去乙酰化酶重要地区,如糖尿病、癌症、心血管功能障碍和神经退行性变疾病已经抛出他们到一个突出地位,作为一个潜在的目标治疗发展营养。会议的重点去乙酰化酶座谈会在代谢、衰老和疾病将解决基本问题的调节上、生化、分子和细胞机制去乙酰化酶及其途径。去乙酰化酶依靠规定的意义的心智就多样的生物有机体,将会被讨论。我们期望,本次会议将评估去乙酰化酶生物学相关性的各种人类的条件,并提供一个独特的环境讨论特异性治疗策略。

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