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 Key individual components of signaling pathways that control lymphocyte activation have been identified. However, their specific regulation, integration within pathways and regulation are still the subject of intense investigation. Currently, they are being probed through biochemical, chemical-genetic, modeling and imaging methods. Major hurdles still reflect our very simplistic understanding of both the kinetic parameters of the molecules involved as well as the complexity of the regulatory circuits of these signaling pathways. Moreover, it is still quite difficult to translate such information into downstream biologically important information. The fact that therapeutics targeting these signaling pathways are still lagging is not surprising. The Keystone Symposia meeting on Regulation of Lymphocyte Signaling will highlight different methodologies and approaches aimed at developing a better integration of complex information about signaling. This information will lead to better understanding of how the normal immune system functions and where interventions in signaling pathways can be used in diseases of the immune system.

个别重点控制淋巴细胞激活的信号通路的组成部分，也已确定。然而，他们的具体规定，途径和规管内的整合仍在紧张调查的主题。目前，他们正在探讨通过生化，遗传，化学建模和成像方法。主要障碍仍然反映我们的分子动力学参数非常简单化的理解，以及监管这些信号通路电路的复杂性。此外，它仍然是相当困难的，这些信息转化到下游具有重要生物学意义的信息。事实上，针对这些信号通路的疗法仍然滞后也就不足为奇了。淋巴细胞信号的规管上的梯形研讨会会议将突出旨在发展的有关信号的复杂的信息更好地融入不同的方法和办法。这个信息将导致更好地了解如何在正常的免疫系统功能和信号转导通路的干预措施可用于免疫系统疾病。

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