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Key individual components of signaling pathways that control lymphocyte activation have been identified. However, their specific regulation, integration within pathways and regulation are still the subject of intense investigation. Currently, they are being probed through biochemical, chemical-genetic, modeling and imaging methods. Major hurdles still reflect our very simplistic understanding of both the kinetic parameters of the molecules involved as well as the complexity of the regulatory circuits of these signaling pathways. Moreover, it is still quite difficult to translate such information into downstream biologically important information. The fact that therapeutics targeting these signaling pathways are still lagging is not surprising. The Keystone Symposia meeting on Regulation of Lymphocyte Signaling will highlight different methodologies and approaches aimed at developing a better integration of complex information about signaling. This information will lead to better understanding of how the normal immune system functions and where interventions in signaling pathways can be used in diseases of the immune system. ¸ö±ðÖصã¿ØÖÆÁÜ°Íϸ°û¼¤»îµÄÐźÅͨ·µÄ×é³É²¿·Ö£¬Ò²ÒÑÈ·¶¨¡£È»¶ø£¬ËûÃǵľßÌå¹æ¶¨£¬Í¾¾¶ºÍ¹æ¹ÜÄÚµÄÕûºÏÈÔÔÚ½ôÕŵ÷²éµÄÖ÷Ì⡣Ŀǰ£¬ËûÃÇÕýÔÚ̽ÌÖͨ¹ýÉú»¯£¬ÒÅ´«£¬»¯Ñ§½¨Ä£ºÍ³ÉÏñ·½·¨¡£Ö÷ÒªÕÏ°ÈÔÈ»·´Ó³ÎÒÃǵķÖ×Ó¶¯Á¦Ñ§²ÎÊý·Ç³£¼òµ¥»¯µÄÀí½â£¬ÒÔ¼°¼à¹ÜÕâЩÐźÅͨ·µç·µÄ¸´ÔÓÐÔ¡£´ËÍ⣬ËüÈÔÈ»ÊÇÏ൱À§Äѵģ¬ÕâЩÐÅϢת»¯µ½ÏÂÓξßÓÐÖØÒªÉúÎïѧÒâÒåµÄÐÅÏ¢¡£ÊÂʵÉÏ£¬Õë¶ÔÕâЩÐźÅͨ·µÄÁÆ·¨ÈÔÈ»ÖͺóÒ²¾Í²»×ãΪÆæÁË¡£ÁÜ°Íϸ°ûÐźŵĹæ¹ÜÉϵÄÌÝÐÎÑÐÌÖ»á»áÒ齫ͻ³öÖ¼ÔÚ·¢Õ¹µÄÓйØÐźŵĸ´ÔÓµÄÐÅÏ¢¸üºÃµØÈÚÈ벻ͬµÄ·½·¨ºÍ°ì·¨¡£Õâ¸öÐÅÏ¢½«µ¼Ö¸üºÃµØÁ˽âÈçºÎÔÚÕý³£µÄÃâÒßϵͳ¹¦ÄܺÍÐźÅתµ¼Í¨Â·µÄ¸ÉÔ¤´ëÊ©¿ÉÓÃÓÚÃâÒßϵͳ¼²²¡¡£ |
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