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 During the past 10 to 15 years, there has been significant progress in our understanding of pancreatic islet development and islet biology. This knowledge has been complemented and accelerated by major advances in diverse fields including islet transplantation, stem cells, small molecule screening, high-throughput sequencing, epigenetics and human genetics. The integration of these divergent disciplines has allowed us to develop a clearer definition of a functional b cell and has elucidated many of the mechanisms underlying the differentiation, survival and death of the b cell. Furthermore, these studies have revealed the potential to generate new b cells through replication or neogenesis. Improvements in differentiation and transdifferentiation protocols have also illustrated the potential of using stem cells and some somatic cell types as sources of islet cells, but these studies have also revealed the challenges associated with generating functional b cells. The purpose of this Keystone Symposia meeting is to highlight the areas of islet biology that have seen the most remarkable advances and to address some of the controversies that still exist in the field, especially with regards to the generation and maintenance of functionally mature b cells for therapeutic purposes. In addition, where it is possible, comparative mouse and human studies will be discussed to illustrate if and when mouse studies can be applied to the human situation.

在过去的10至15年，已经在我们的胰岛发展和胰岛生物学的理解方面取得了重大进展。这方面的知识补充，并在不同的领域，包括胰岛移植，干细胞，小分子筛选，高通量测序，表观遗传学和人类遗传学的重大进展加快。这些不同学科的整合，使我们能够开发出功能的B细胞有更明确的定义，并阐明许多潜在的B细胞的分化，存活和死亡的机制。此外，这些研究均显示可能产生新的B细胞通过复制或再生。分化和转分化协议的改进也说明了使用胰岛细胞来源的干细胞和一些体细胞类型的潜力，但这些研究??也显示功能的B细胞产生关联的挑战。这个梯形的专题讨论会会议的目的是为了突出所看到的最显着的进步胰岛生物学领域，并解决一些在该领域仍然存在争议，特别是关于功能的成熟B细胞的生成和维护治疗目的。此外，有可能的情况下，比较老鼠和人类的研究讨论，说明小鼠的研究时，可以应用到人类的处境。

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