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Inflammation is inextricably woven into the natural history of atherosclerosis. The macrophage is integral to the pathogenesis of atherosclerosis, functioning at the intersection of inflammation and cholesterol homeostasis, making its biological properties an important topic. Consequently, macrophage biology will be a major focus of the Keystone Symposia meeting on Molecular Basis of Vascular Inflammation and Atherosclerosis. The critical contributions of innate and adaptive immunities to atherosclerosis will also be reviewed, and a session on fundamental features of the inflammatory process, including its resolution, will introduce concepts likely to influence future paradigms in the atherosclerosis field. Recently discovered factors that regulate levels of atherogenic lipoproteins, key initiators of arterial inflammation, will be presented. Other highlights include progress in genomic approaches to discover risk factors for coronary artery disease, as well as advances in imaging techniques to detect atherosclerotic plaques, cellular composition of plaques and trafficking of immune cells in vivo. The keynote address will highlight emerging roles of nuclear hormone receptors as integrators of plaque lipid metabolism and immune activity. Ñ×Ö¢ÊǶ¯ÂöÖàÑùÓ²»¯µÄ×ÔÈ»ÀúÊ·ÓÐ×Åǧ˿ÍòÂÆÖ¯³É¡£¾ÞÊÉϸ°ûÊǶ¯ÂöÖàÑùÓ²»¯µÄ·¢²¡»úÖƵÄ×é³É²¿·Ö£¬ÔÚÑ×Ö¢ºÍµ¨¹Ì´¼Æ½ºâÔË×÷£¬ÆäÉúÎïѧÌØÐÔµÄÒ»¸öÖØÒª¿ÎÌâ¡£Òò´Ë£¬¾ÞÊÉϸ°ûÉúÎïѧµÄÖ÷Òª½¹µã½«ÊÇÒ»¸öÌÝÐÎרÌâÌÖÂÛ»á»áÒéÉϵÄѪ¹ÜÑ׺Ͷ¯ÂöÖàÑùÓ²»¯µÄ·Ö×Ó»ù´¡µÄ¡£ÓÐÏÈÌìÃâÒߺÍÊÊÓ¦ÐԵĻíÃâȨ¶¯ÂöÖàÑùÓ²»¯µÄÖØÒª¹±Ï×£¬Ò²½«½øÐÐÉó²é£¬¶ÔÑ×Ö¢¹ý³ÌÖеĻù±¾ÌØÕ÷£¬°üÀ¨ÆäµÚµÄ»áÒ飬½«Òý½øÔÚ¶¯ÂöÖàÑùÓ²»¯ÁìÓò¿ÉÄÜÓ°Ï쵽δÀ´µÄ·¶Ê½¸ÅÄî¡£×î½ü·¢ÏÖµÄÒòËØ£¬µ÷½Ú¶¯ÂöÖàÑùÓ²»¯µÄÖ¬µ°°×µÄˮƽ£¬¶¯ÂöÑ׵Ĺؼü·¢ÆðÈË£¬½«Ìá½»¡£ÆäËû¾«²Ê½ÚÄ¿°üÀ¨»ùÒò·½·¨µÄ½øÕ¹£¬·¢ÏÖ¹Ú×´¶¯Âö¼²²¡µÄΣÏÕÒòËØ£¬ÒÔ¼°ÔÚ³ÉÏñ¼¼ÊõµÄ½ø²½À´¼ì²â¶¯ÂöÖàÑùÓ²»¯°ß¿é£¬°ß¿éºÍ··ÂôÌåÄÚµÄÃâÒßϸ°ûµÄϸ°û×é³É¡£Ö÷ÌâÑݽ²½«Í»³ö¼¯³É°ß¿éÖ¬ÖÊ´úлºÍÃâÒß»îÐԵĺ˼¤ËØÊÜÌåµÄÐÂÐ˽ÇÉ«¡£ |
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