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Gene expression in eukaryotes is regulated primarily at the level of transcription. Biochemical, genetic and molecular genetic analyses of a handful of genes have provided a basic understanding of transcription. Advances in proteomics have rapidly expanded the repertoire of proteins and protein-protein interactions that participate in gene expression, and genome-wide analyses of protein distributions across genomes and gene expression are expanding and challenging our knowledge. For example, RNA polymerase II is found concentrated at the promoters of thousands of genes, causing much interest in the field to shift focus to the role of elongation in regulating gene expression. The functions of vast noncoding, transcribed regions of the genome are largely unknown. HDACs, thought to function primarily as repressors, tend to be associated with highly transcribed genes. This meeting will explore new and exciting aspects of eukaryotic gene regulation emerging from genomic, proteomic and other high-throughput techniques. ÔÚÕæºËÉúÎïÖлùÒò±í´ïµÄµ÷½ÚÖ÷ÒªÊÇÔÚת¼ˮƽ¡£ÉÙÊý»ùÒòµÄÉú»¯£¬ÒÅ´«ºÍ·Ö×ÓÒÅ´«·ÖÎöÌṩÁËÒ»¸ö»ù±¾µÄÁ˽âת¼¡£µ°°×ÖÊ×éѧÑо¿½øչѸËÙÀ©´óµÄµ°°×ÖʺͲÎÓë»ùÒò±í´ïµÄµ°°×ÖÊ - µ°°×ÖÊÏ໥×÷ÓõľçÄ¿£¬ºÍÕû¸ö»ùÒò×éºÍ»ùÒò±í´ïµÄµ°°×ÖÊ·Ö²¼µÄÈ«»ùÒò×é·ÖÎöÀ©´óºÍÌôÕ½ÎÒÃǵÄ֪ʶ¡£ÀýÈ磬RNA¾ÛºÏøII·¢ÏÖ¼¯ÖÐÔÚ³ÉǧÉÏÍò¸ö»ùÒòµÄ´ÙÏúÔ±£¬µ¼ÖÂÔÚ¸ÃÁìÓòµÄ¼«´óÐËȤ£¬ÔÚµ÷½Ú»ùÒò±í´ïµÄÖصãתÒƵ½É쳤µÄ×÷Ó᣹ã´ó·Ç±àÂëµÄ¹¦ÄÜ£¬»ùÒò×éµÄת¼ÇøÓòÔںܴó³Ì¶ÈÉÏÊÇδ֪µÄ¡£»¯Ã¸£¬ÈÏΪÖ÷Òª¹¦ÄÜ×è¶ô£¬ÍùÍùÊǸßת¼»ùÒòÏà¹Ø¡£±¾´Î»áÒ齫̽ÌÖеĺÍÁîÈËÐ˷ܵķ½Ã棬´Ó»ùÒò×éѧ£¬µ°°×ÖÊ×éѧºÍÆäËû¸ßͨÁ¿¼¼ÊõµÄ³öÏÖÕæºË»ùÒòµ÷¿Ø¡£ |
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