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 It has become apparent that RNA plays a major, but still largely unexplored, role in the regulation of gene expression. It is becoming increasingly evident that longer forms of non-protein-coding RNAs (ncRNAs) are involved directly in regulating gene expression and epigenetic states. These long ncRNAs appear to be functioning as an endogenous RNA regulatory system, playing a major role in the epigenetic control of differentiation and development. These observations, across various model systems, strongly suggest that long ncRNAs are more intricately involved in the regulation of gene expression than previously envisioned. The goal of the Keystone Symposia meeting on Non-Coding RNAs is to highlight the similarities and differences in various model systems to better understand the role of long ncRNAs in the regulation of genomes. This is an entirely new emerging field of study that is on the forefront of modern biology. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Eukaryotic Transcription, which will share a plenary session with this meeting.

它已成为明显的RNA扮演着重要的，但很大程度上仍是未开发的，在基因表达调控中的作用。这是日益明显的是较长形式的非蛋白编码RNA（非编码RNA）直接参与调控基因表达和表观状态。这些长期的非编码RNA作为内源性RNA的规管制度的运作，扮演一个主要角色的分化和发育的表观遗传控制。这些意见，在各种模型系统，强烈建议长非编码RNA在基因表达的调控，比原先预想的更加错综复杂。非编码RNA的梯形专题讨论会会议的目的是为了突出各种模型系统的相似性和差异，以便更好地了解基因组调控的长非编码RNA的作用。这是一个全新的新兴研究领域，是现代生物学的前沿。并发会议真核生物转录，将与本次会议的全体会议上，跨学科的互动的机会将显着增强。

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