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 A fundamental goal of neuroscience is to understand the molecular, cellular and activity-based mechanisms that control the formation and maintenance of neural circuits and determine how these mechanisms become compromised in neurodevelopmental, psychiatric and neurodegenerative disorders. Over the past two decades, molecular neuroscientists have identified key molecules and mechanisms that underlie synapse development, activity and stability. Meanwhile, the study of neuronal circuits has been revolutionized by new methods to visualize and map circuits in living animals, as well as the development of approaches to control neuronal activity using optical approaches (so called optogenetics). Finally, disease researchers have identified genes associated with neurodevelopmental and psychiatric disorders and neurodegenerative diseases. Animal models of these diseases are proving useful to understand how dysfunction of affected genes and proteins contributes to disease pathology. Although these fields are working on the same processes, no small highly interactive meeting brings these three groups together. The Keystone Symposia meeting on Synapses and Circuits: From Formation to Disease will address this need by bringing together leaders working on synapse development and function, circuit structure and function and the study of brain disease. We anticipate that mutually beneficial insights will emerge from discussions at this meeting.

一个神经科学的基本目标是了解的分子，细胞和活动为基础的的机制，控制神经回路的形成和维护，并确定这些机制如何成为神经发育，精神和神经退行性疾病的损害。在过去的二十年中，分子神经科学家已确定的关键分子和机制，突触发育，活性和稳定性的基础。同时，神经回路的研究已彻底改变了新的方法来可视化和地图在动物活体电路，以及发展的办法来控制神经元的活动，利用光学方法（即所谓的光遗传学）。最后，疾病的研究人员已经确定了与神经发育和精神疾病和神经退行性疾病相关的基因。这些疾病的动物模型，有助于理解如何受影响的基因和蛋白质功能障碍疾病的病理。虽然这些领域是在同一过程中的工作，不小的高度互动的会议带来了这三组。突触和电路的梯形专题讨论会会议：从形成到疾病汇集领导人在突触发育和功能，电路结构和功能和脑血管疾病的研究工作将解决这方面的需要。我们预计，互惠互利的见解会出现在本次会议讨论。

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